diff --git a/test/topology_custom/test_tablets_migration.py b/test/topology_custom/test_tablets_migration.py
new file mode 100644
index 0000000000..e1ed3d637b
--- /dev/null
+++ b/test/topology_custom/test_tablets_migration.py
@@ -0,0 +1,91 @@
+#
+# Copyright (C) 2024-present ScyllaDB
+#
+# SPDX-License-Identifier: AGPL-3.0-or-later
+#
+from cassandra.query import SimpleStatement, ConsistencyLevel
+from test.pylib.manager_client import ManagerClient
+from test.pylib.rest_client import HTTPError
+from test.pylib.tablets import get_all_tablet_replicas
+from test.topology.conftest import skip_mode
+import pytest
+import logging
+import asyncio
+
+logger = logging.getLogger(__name__)
+
+
+@pytest.mark.parametrize("fail_replica", ["source", "destination"])
+@pytest.mark.parametrize("fail_stage", ["streaming"])
+@pytest.mark.asyncio
+@skip_mode('release', 'error injections are not supported in release mode')
+async def test_node_failure_during_tablet_migration(manager: ManagerClient, fail_replica, fail_stage):
+    logger.info("Bootstrapping cluster")
+    cfg = {'enable_user_defined_functions': False, 'experimental_features': ['tablets', 'consistent-topology-changes']}
+    host_ids = []
+    servers = []
+
+    async def make_server():
+        s = await manager.server_add(config=cfg)
+        servers.append(s)
+        host_ids.append(await manager.get_host_id(s.server_id))
+        await manager.api.disable_tablet_balancing(s.ip_addr)
+
+    await make_server()
+    cql = manager.get_cql()
+
+    await cql.run_async("CREATE KEYSPACE test WITH replication = {'class': 'NetworkTopologyStrategy', 'replication_factor': 2} AND tablets = {'initial': 1}")
+    await make_server()
+    await cql.run_async("CREATE TABLE test.test (pk int PRIMARY KEY, c int);")
+
+    keys = range(256)
+    await asyncio.gather(*[cql.run_async(f"INSERT INTO test.test (pk, c) VALUES ({k}, {k});") for k in keys])
+    await make_server()
+
+    logger.info(f"Cluster is [{host_ids}]")
+
+    replicas = await get_all_tablet_replicas(manager, servers[0], 'test', 'test')
+    logger.info(f"Tablet is on [{replicas}]")
+    assert len(replicas) == 1 and len(replicas[0].replicas) == 2
+
+    old_replica = None
+    for r in replicas[0].replicas:
+        assert r[0] != host_ids[2], "Tablet got migrated to node2"
+        if r[0] == host_ids[1]:
+            old_replica = r
+    assert old_replica is not None
+    new_replica = (host_ids[2], 0)
+    logger.info(f"Moving tablet {old_replica} -> {new_replica}")
+
+    fail_idx = 1 if fail_replica == "source" else 2
+
+    logger.info(f"Will fail {fail_stage}")
+    if fail_stage == "streaming":
+        await manager.api.enable_injection(servers[2].ip_addr, "stream_mutation_fragments", one_shot=True)
+        s2_log = await manager.server_open_log(servers[2].server_id)
+        s2_mark = await s2_log.mark()
+    else:
+        assert False, f"Unknown stage {fail_stage}"
+
+    migration_task = asyncio.create_task(
+        manager.api.move_tablet(servers[0].ip_addr, "test", "test", old_replica[0], old_replica[1], new_replica[0], new_replica[1], 0))
+
+    logger.info(f"Wait for {fail_stage} to happen")
+    if fail_stage == "streaming":
+        await s2_log.wait_for('stream_mutation_fragments: waiting', from_mark=s2_mark)
+    else:
+        assert False
+
+    logger.info(f"Stop {fail_replica} {host_ids[fail_idx]}")
+    await manager.server_stop(servers[fail_idx].server_id)
+    logger.info(f"Remove {fail_replica} {host_ids[fail_idx]}")
+    await manager.remove_node(servers[0].server_id, servers[fail_idx].server_id)
+
+    logger.info("Done, waiting for migration to finish")
+    await migration_task
+
+    replicas = await get_all_tablet_replicas(manager, servers[0], 'test', 'test')
+    logger.info(f"Tablet is now on [{replicas}]")
+    assert len(replicas) == 1
+    for r in replicas[0].replicas:
+        assert r[0] != host_ids[fail_idx]