diff --git a/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts b/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts
index 30aed7632e..5aafa19a2f 100644
--- a/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts
+++ b/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts
@@ -350,6 +350,7 @@ function validateEffect(
     sourceIds: Set<IdentifierId>;
   }> = [];
 
+  const globals: Set<IdentifierId> = new Set();
   for (const block of effectFunction.body.blocks.values()) {
     for (const pred of block.preds) {
       if (!seenBlocks.has(pred)) {
@@ -393,6 +394,16 @@ function validateEffect(
           // If the callee is a prop we can't confidently say that it should be derived in render
           return;
         }
+
+        if (globals.has(instr.value.callee.identifier.id)) {
+          // If the callee is a global we can't confidently say that it should be derived in render
+          return;
+        }
+      } else if (instr.value.kind === 'LoadGlobal') {
+        globals.add(instr.lvalue.identifier.id);
+        for (const operand of eachInstructionOperand(instr)) {
+          globals.add(operand.identifier.id);
+        }
       }
     }
     seenBlocks.add(block.id);
diff --git a/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-global-function-call-no-error.expect.md b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-global-function-call-no-error.expect.md
new file mode 100644
index 0000000000..e17f1e26f6
--- /dev/null
+++ b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-global-function-call-no-error.expect.md
@@ -0,0 +1,70 @@
+
+## Input
+
+```javascript
+// @validateNoDerivedComputationsInEffects_exp
+import {useEffect, useState} from 'react';
+
+function Component({propValue}) {
+  const [value, setValue] = useState(null);
+  useEffect(() => {
+    setValue(propValue);
+    globalCall();
+  }, [propValue]);
+
+  return <div>{value}</div>;
+}
+
+export const FIXTURE_ENTRYPOINT = {
+  fn: Component,
+  params: [{propValue: 'test'}],
+};
+
+```
+
+## Code
+
+```javascript
+import { c as _c } from "react/compiler-runtime"; // @validateNoDerivedComputationsInEffects_exp
+import { useEffect, useState } from "react";
+
+function Component(t0) {
+  const $ = _c(5);
+  const { propValue } = t0;
+  const [value, setValue] = useState(null);
+  let t1;
+  let t2;
+  if ($[0] !== propValue) {
+    t1 = () => {
+      setValue(propValue);
+      globalCall();
+    };
+    t2 = [propValue];
+    $[0] = propValue;
+    $[1] = t1;
+    $[2] = t2;
+  } else {
+    t1 = $[1];
+    t2 = $[2];
+  }
+  useEffect(t1, t2);
+  let t3;
+  if ($[3] !== value) {
+    t3 = <div>{value}</div>;
+    $[3] = value;
+    $[4] = t3;
+  } else {
+    t3 = $[4];
+  }
+  return t3;
+}
+
+export const FIXTURE_ENTRYPOINT = {
+  fn: Component,
+  params: [{ propValue: "test" }],
+};
+
+```
+      
+### Eval output
+(kind: exception) globalCall is not defined
\ No newline at end of file
diff --git a/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/error.effect-with-global-function-call-no-error.js b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-global-function-call-no-error.js
similarity index 100%
rename from compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/error.effect-with-global-function-call-no-error.js
rename to compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-global-function-call-no-error.js